thymidylate synthase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2627	Nolatrexed dihydrochloride	Thymitaq,AG 337	DNA/RNA Synthesis
	Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidyla...		DNA/RNA Synthesis
T33762	Fosifloxuridine nafalbenamide	NUC-3373,NUC3373,NUC 3373	DNA/RNA Synthesis
	Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. NUC-3373 has anticancer activity. NUC-3373 is a ProTide transformation of 5-FU that generates much higher c...		DNA/RNA Synthesis
T3658	Trifluridine/tipiracil hydrochloride mixture	Trifluridine-tipiracil hydrochloride mixture,TAS102,TAS-102,TAS 102	Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 2:1.		Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
T6632	Raltitrexed	ZD1694,D1694,ICI-D1694,Tomudex	Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.		Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
T1428	Trifluridine	NSC 529182,Trifluorothymidine,5-Trifluorothymidine,NSC 75520,Viroptic,Trifluridina	Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , HSV
	Trifluridine (NSC-75520) is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibi...		Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , HSV
T4228	Nolatrexed		DNA/RNA Synthesis
	Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.		DNA/RNA Synthesis
T27399	Galocitabine	RO 091390,RO-091390,RO091390,RO-09-1390,Neofrutulon	Others
	Galocitabine (Neofrutulon), a thymidylate synthase inhibitor, is used potentially for the treatment of cancer.		Others
T0189	Pemetrexed	Pemetrexed acid,LY231514,LY-231514 Disodium Hydrate	DHFR , DNA/RNA Synthesis , Antifolate , Autophagy
	Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).		DHFR , DNA/RNA Synthesis , Antifolate , Autophagy
T0964	Floxuridine	5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640	Apoptosis , Nucleoside Antimetabolite/Analog , Others , DNA/RNA Synthesis , Antibacterial , HSV
	Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
T0984	5-Fluorouracil	5-FU,Fluorouracil,NSC 19893,5-Fluoracil	Apoptosis , Nucleoside Antimetabolite/Analog , HIV Protease , DNA/RNA Synthesis , Endogenous Metabolite
	5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis. 5-Fluorouracil has antitumor activity and affects pyrimidine synthesis through inhibition of thymidylate synthase. 5-Fluorouracil causes apoptosis ...
T19833	5-Fluoroorotic acid		DNA/RNA Synthesis , Antifungal
	5-Fluoroorotic acid is an inhibitor of thymidylate synthase. 5-Fluoroorotic is a selective agent in yeast molecular genetics.5-Fluoroorotic possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine...		DNA/RNA Synthesis , Antifungal
T21314	Amsilarotene	TAC-101,TAC 101,TAC101	CDK
	Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cy...		CDK
T4382	Proguanil hydrochloride	Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil	Others , Dehydrogenase , DNA/RNA Synthesis , Antifolate , Parasite
	Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine ...
T1852	Rac-Belinostat	NSC726630,PXD101,PX-105684	HDAC
	Rac-Belinostat (PX-105684) is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptos...		HDAC
T25519	ICI 198583	CB 3819,ICI198583,ICI-198583
	ICI 198583 is an inhibitor of antifolate thymidylate synthase.
T30760	CB 30900	CB30900,CB-30900
	CB30900 is a novel and effective thymidylate synthase inhibitor.
T30761	CB 3703	CB3703,NSC 289522,CB-3703
	CB 3703 is an inhibitor of dihydrofolate reductase and thymidylate synthase.
T21315	Folitixorin	ANX-510
	ANX-510 is a folate-based biomodulator. It stabilizes the covalent binding of the fluorouracil metabolite FdUMP to thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphos...
T24454	Metesind Glucuronate	AG 331,AG331,AG-331
	Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.
T24572	OSI-7904L free acid	OSI 7904,OSI-7904L,OSI7904,OSI 7904L,OSI7904L,OSI-7904
	OSI-7904L is a folate-based thymidylate synthase inhibitor. It also has antimalarial and antitumor properties.